compared with a rate of 6–20% in cerebral malaria. Data on the prevalence of HMS is scant, but in areas with intense transmission of malaria. malarial splenomegaly. SIR—Hyper-reactive malarial splenomegaly (HMS) is a form of severe malaria, with a mortality rate that exceeds 50%,1,2 compared with . ABSTRACT. Hyper-reactive malarial splenomegaly (HMS) or Tropical splenomegaly syndrome(TSS), occurs in areas of high transmission of.

Author: Kagakree Zulkishakar
Country: Switzerland
Language: English (Spanish)
Genre: Literature
Published (Last): 4 November 2018
Pages: 138
PDF File Size: 2.90 Mb
ePub File Size: 2.68 Mb
ISBN: 672-5-45193-154-6
Downloads: 64257
Price: Free* [*Free Regsitration Required]
Uploader: Yozshushura

Hyper-reactive malarial splenomegaly in the absence of raised IgM antibodies. It reflects the view that the syndrome tends to evolve even though malaria parasites are no longer present in blood.

The hyper-reactive malarial splenomegaly: a systematic review of the literature

She was commenced on chloroquine mg weekly and proguanil mg OD. An initial amplification of the outer regions of the two genes was followed by a nested PCR with allelic family specific primer pairs [ 13 ]. Treatment of hyperreactive malarial splenomegaly syndrome. Splenectomy, associated with high mortality, should be strictly limited to cases not responding to medical treatment.

Rovere PA, Bisoffi Z. No evidence of chronic malaria.

However, other authors observed that the syndrome tended to malsrial relapse once anti-malarial therapy was stopped [ 7578 ]. However, the liver tended to progressively enlarge, probably related to persistence of the antigenic stimulus [ 95 ]. A cross-sectional study was carried out from January to December In case of differences, a final consensus was reached after discussion that included a third reviewer ZB.


The hyper-reactive malarial splenomegaly: a systematic review of the literature

Journal of Tropical Medicine. However, the occurrence of HMS in tribal and family clusters suggests host genetic factors involvement in the control of the IgM overproduction seen in these patients.

Ann Trop Med Parasitol. Clinical hematological and immunological characteristic of Splenomegapy patients. Further testing showed a high antimalarial antibody titer and raised total IgM. Acute Plasmodium falciparum malaria following splenectomy for suspected lymphoma in 2 patients.

Epidemiology, malarial antibody and immunoglobulin levels. The most common prescription, just as in endemic countries, was chloroquine alone [ 54838588 ], or in combination with doxycycline [ 46 ], with proguanil [ 428589 ] or with primaquine [ 90 ], or preceded by a short course of quinine [ 1983 splenomegalt, 88 ] or halofantrine [ 83 ]. It was observed that some of those patients, if further exposed to malaria, evolved to the complete syndrome, and this suggested the possibility to make the diagnosis at an early stage [ 43 ].

The most recent one was carried out in Sudan in and reported, after a three-month therapy, a complete normalization of the spleen size in 14 patients out of 21 [ 69 ].


Other studies confirmed the efficacy of this regimen [ 273171 ]. Report of five cases.

Tropical splenomegaly syndrome – Wikipedia

Tropical splenomegaly in New Guinea. According to historical data, the syndrome is often fatal if left untreated [ 20 ].

Languages Polski Edit links. J Natl Med Assoc. Most patients had lived for at least five years in an endemic area.

About three cases in Italian missionaries. Evolutive visceral malaria and hyperimmune splenometaly splenomegaly: N Engl J Med. A year-old woman from Cote d’Ivoire was referred for investigation of splenomegaly and pancytopenia. Tropical splenomegaly syndromealso known as hyperreactive malarial splenomegalysplenomeglay due immunological over-stimulation to repeated attacks of malarial infection over a long period of time.

This is also suggested by the unusual case of HMS reported above [ 67 ]: Immunological characteristics of hyperreactive malarial splenomegaly syndrome in sudanese patients.